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glutamic acid

CAS No. 56-86-0

glutamic acid( Glutamic Acid | Glutamicol | AI3-18472 )

Catalog No. M18825 CAS No. 56-86-0

(S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    glutamic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    (S)-Glutamic acid acts as an excitatory transmitter, shows a direct activating effect on the release of DA from dopaminergic terminals.
  • Description
    Glutamic Acid is a non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
  • In Vitro
    Cell Viability Assay Cell Line:SH-SY5Y, IMR-32, SK-N-BE(2)Concentration:2, 5, 10, 20 mM Incubation Time:24 and 48 h Result:Reduced cell viability in a dose-dependent manner.
  • In Vivo
    Animal Model:Crv4 mice model Dosage:3 g/kg Administration:s.c., single dose Result:Reduced the number of Brn-3a+ RGCs by >70%.In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.Animal Model:CPF-induced rat model Dosage:750 mg/kg Administration:i.p.Result:Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
  • Synonyms
    Glutamic Acid | Glutamicol | AI3-18472
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    56-86-0
  • Formula Weight
    147.13
  • Molecular Formula
    C5H9NO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 6.25 mg/mL (42.48 mM)
  • SMILES
    C(CC(=O)O)C(C(=O)O)N
  • Chemical Name
    L-glutamic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.
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